Renal excretion of unchanged modafinil normally accounts for less than 10% of an oral dose. Consequently when modafinil is taken by mouth, under ten% of your drug is eliminated from the human body through the urine with out staying metabolized via the liver or other organs.Taking Provigil with monoamine oxidase inhibitors (MAOIs) may possibly cause

They observed the 5-HT3 receptor antagonist MDL72222 alone was in the position to attenuate this impact Just about around the overall serotonin antagonist methysergide, indicating that modafinil labored to reduce GABA partly through a serotonergic pathway mediated largely with the five-HT3 receptor.For oral dosage variety (tablets): For narcolepsy